Organic anion transporter inhibitor
WitrynaOrganic Anion Transporter. Organic anion transporters (OATs) belong to the SLC22A family of solute-carriers, which facilitate the cellular uptake of a wide range of … Members of the Organo Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs are present in the lipid bilayer of the cell membrane, acting as the cell's gatekeepers. OATPs belong to the Solute Carrier Family (SLC) and the major facilitator superfamily.
Organic anion transporter inhibitor
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Witryna1 lut 2024 · As a member of the solute carrier 22A (SLC22A) family, organic anion transporter 2 (OAT2; SLC22A7) is emerging as an important drug transporter because of its expression in both the liver and kidney, two major eliminating organs, and its ability to transport not only a wide variety of xenobiotics but also numerous physiologically … Cyclosporin A (CyA) has potent inhibitory activity on organic anion transporting polypeptide 1B (OATP1B), causing drug–drug interactions ...
WitrynaOrganic Anion Transporter OAT1 (SLC22A6) and OAT3 (SLC22A8) Transporters are validated, stable and robust cell-based assays ... Thus, co-dosing a compound which is an OAT substrate with an OAT inhibitor can lead to reduced renal clearance, higher plasma levels, and increased negative side effects. As an example, the interaction … WitrynaAbstract. Objectives: Recent reports indicated that reduced SLC22A7 (a gene-encoding organic anion transporter 2) expression in noncancerous liver tissue predicts hepatocellular carcinoma (HCC) recurrence after curative resection. Our study aimed to elucidate the association between SLC22A7 expression and HCC development in …
Witryna24 maj 2012 · Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions The … Witryna1 sty 2015 · The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention because of its role in handling of common drugs (antibiotics, antivirals, diuretics, nonsteroidal anti-inflammatory drugs), toxins (mercury, aristolochic acid), and …
Witryna9 cze 2010 · An in vivo study revealed that probenecid, a typical inhibitor of organic anion transporters (OATs), inhibited the renal clearance of OTA . In addition, glomerular filtration of OTA is considered to be minimal, since more than 99% of OTA is bound to plasma proteins [15,16]. From these results, it is thought that the excretion of OTA …
WitrynaMay contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins) such as pitavastatin, a clinically important class of hypolipidemic drugs ( PubMed: 15159445 ). May play an important role in plasma and tissue distribution of … lg 2.0 cu. ft. neocheftm countertop microwaveWitrynaCommon to all so far functionally characterized Organic Anion Transporters (OATs) is their broad substrate specificity and their ability to exchange extracellular against … lg 20 inch smart tvWitryna2 sie 2010 · Organic anion transporting polypeptides (OATPs) are uptake transporters for a broad range of endogenous compounds and xenobiotics. To investigate the physiologic and pharmacologic roles of OATPs of the 1A and 1B subfamilies, we generated mice lacking all established and predicted mouse Oatp1a/1b transporters … mcdonalds familyWitryna2. Hsiang, B., et al., A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem, 1999. 274(52): p. 37161-8. 3. mcdonalds facturarWitrynaOrganic anion transporter 3 (OAT3) plays a significant role in the uptake of methotrexate into the renal proximal tubule cells. Therefore, inhibitors of organic … mcdonalds family nightWitryna Aims lg 20 ltr convection microwaveWitrynaOatp1b2 (organic anion transporting polypeptide 1b2), rat. Rat Oatp1b2 (Slco1b2) is a sodium-independent transporter selectively expressed in the sinusoidal (basolateral) plasma membrane of hepatocytes [1-3]. As one of the organic anion transporting polypeptides (Oatp/OATP), this transporter is a member of the solute carrier … lg 20k cell phone