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WebThe objective of this study was to identify the natural compounds that inhibit MSTN with therapeutic potential for the management of age-related disorders, specifically muscle atrophy and sarcopenia. Sequential screening of 2000 natural compounds was performed, and dithymoquinone (DTQ) was found to inhibit MSTN with a binding free energy of … WebAs shown in Table 1, the partition coefficients of insulin, C1, and C2 were 0.0041 ± 0.0004, 0.5339 ± 0.1131, and 0.0241 ± 0.0075, respectively. The partition coefficient of the C1 nanocomplex was 22.15-fold greater than that of C2, suggesting that C1 was more lipophilic. sancroft road harrow
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