Nettet8. okt. 2024 · This frequently manifests itself as a different transcriptional programme and cellular plasticity that is associated with a phenotypic switch including EMT, transdifferentiation to a different... NettetOur study provides mechanistic insights into the plasticity of the lineage-infidelity state governed by AR reprogramming that enabled us to redirect cell fate by modulating EZH2 and AR, highlighting the clinical potential of reversing resistance phenotypes. © 2024. The Author (s), under exclusive licence to Springer Nature Limited.
Cell Lineage Infidelity in PDAC Progression and Therapy Resistance
http://yejinggelab.com/research/ NettetIn pancreatic ductal adenocarcinoma (PDAC), the role of lineage infidelity and phenotype switching is still unclear. Two consensus molecular subtypes of PDAC have been … knee exercises tahir hasan
Lineage Infidelity in Acute Leukemia - ScienceDirect
Nettet22. sep. 2024 · Therapeutic resistance in prostate cancer can be driven by lineage plasticity, but the mechanisms behind this are unclear, and therapies to prevent or reverse the process are nonexistent. A new... Nettet(8) This finding supports the concept of lineage fidelity, and suggests that true interlineage infidelity, myeloid to lymphoid, is a rare occurrence in adult acute nonlymphocytic leukemia. (9) In recent weeks Trump has been cranking up his gender attacks on Clinton, accusing her of playing the woman card and criticising her for being an “enabler” of her … NettetDefinition: (n.) One who holds to a heresy; one who believes some doctrine contrary to the established faith or prevailing religion. (n.) One who having made a profession of Christian belief, deliberately and pertinaciously refuses to believe one or more of the articles of faith "determined by the authority of the universal church." knee exercises meniscus tear