High affinity copper uptake protein
WebBecause copper uptake at the cell membrane is a crucial step in copper acquisition, yeast genes encoding the high affinity copper transport proteins are tightly regulated in response to copper levels to ensure that … WebCatalog FieldsAntigen: High affinity copper uptake protein 1Available to For-Profits: YesAntigen Species: HumanHybridoma Cells Available (Non-Profit): NoIsotype: MIgG2bDepositor: Clinical Proteomics Technologies for CancerHost Species: mouseAntigen Sequence: Positive Tested Species Reactivity: HumanDepositors Institution: National …
High affinity copper uptake protein
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WebThe redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. However, little is known … WebCopper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily …
Web149 Likes, 9 Comments - Joshua Rubin (@realfoodgangstas) on Instagram: "10 Things You Can Do Today to Replenish Zinc Status to Support Thyroid Health Lets talk about ... Web1 de abr. de 2014 · As previously mentioned, high-affinity Fe uptake at the plasma membrane depends in S. cerevisiae on Fet3 ferroxidase, which uses Cu as an indispensable cofactor for its activity. Therefore, Cu deficiency leads to impaired Fe transport in yeast, and consequently to multiple Fe-related symptoms [ 61 ].
WebGene ID: 102804936, updated on 5-Feb-2024. Summary Other designations. high affinity copper uptake protein 1-like WebChimera protein of High affinity copper uptake protein 1 and Soluble cytochrome b562HEXATANTALUM DODECABROMIDEZINC ION. NCBI. National Center for Biotechnology Information. Search. 6M97: Crystal structure of the high-affinity copper transporter Ctr1. PDB ID: 6M97 Download: MMDB ID: 173912: PDB Deposition Date:
Webhigh-affinity copper uptake (17, 18). Based on its copper-transporting function in a yeast assay, its sequence similarity to the yeast high-affinity copper uptake protein, and its ubiquitous expression, we hypothesized that CTR1 is required for copper uptake in mammalian cells (4). Indeed two recent studies, involving 64Cu uptake (19) and ...
Web12 de abr. de 2024 · To overcome this challenge, bacteria synthesize high-affinity iron-binding molecules called siderophores, which are recognized by specific transporters on the cell surface. Trojan horse antibiotics have evolved to hijack these transporters for uptake across the outer membrane (OM). howrah station loungeWebCTR1, high affinity copper uptake protein 1; ATP7A, copper-transporting ATPase 1; CCO, cytochrome C oxidase; ATOX1, copper transport protein ATOX1; KRAS, Kirsten rat sarcoma 2 viral oncogene homolog. Display full size. Figure 1. KRAS-driven colorectal cancer (CRC) cells are addicted to copper metabolism. howrah station to mayapur distanceWebIt was shown that a gene, CTR1, encoded a multispanning plasma membrane protein that was specifically required for high affinity copper transport into yeast.The CTR1 gene product is a protein composed of 406 amino acid residues. A second high affinity copper uptake protein, encoded by the CTR3 gene, was subsequently identified. The two gene … howrah station executive lounge bookingHigh affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene. Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, … Ver mais In 2024, a new autosomal-recessive disease was discovered that is caused by mutations of the CTR1 gene. The disease is characterized by profound deficiency of copper in the central nervous system and presents with … Ver mais • Solute carrier family Ver mais • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". … Ver mais merlyn arysto 8 infold doorWeb8 de abr. de 2024 · HIGHLIGHTS. who: Nina Salustros from the (UNIVERSITY) have published the research: Structural basis of ion uptake in copper-transporting P1B-type ATPases, in the Journal: (JOURNAL) of 16/08/2024 what: Transport and regulation mechanism Based on detailed analyses of the structurally determined E1 state and … howrah station retiring roomWeb15 de mar. de 1996 · Two proteins in the plasma membrane of yeast—a multicopper oxidase, encoded by the FET3 gene, and a permease, encoded by the FTR1 gene—were shown to mediate high-affinity iron uptake. FET3 expression was required for FTR1 protein to be transported to the plasma membrane. merlyn bath screen fitting instructionsWebOne way that some methanotrophs obtain copper is by production and secretion of methanobactins (Mbns), ribosomally synthesized, posttranslationally modified peptide natural products that bind Cu I with high affinity ().The protein machinery to manufacture and transport Mbns is encoded by operons, which are down-regulated under copper … howrah station to kasba