Efficient synthesis of scutellarein
WebFeb 25, 2016 · Synthesis. 1- (6-Hydroxy-2,3,4-trimethoxyphenyl)ethanone ( 4 ): To a stirring solution of 3 (10 g, 54.5 mmol) in BF 3 ·Et 2 O (25 mL) was added CH 3 COOH (15 mL). After stirring under N 2 atmosphere at 85 °C for 2.5 h, the reaction mixture was allowed to warm to room temperature. Then ice water (50 mL) was added slowly.
Efficient synthesis of scutellarein
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WebOct 19, 2011 · Europe PMC is an archive of life sciences journal literature. WebScutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on …
Webpractical method for the synthesis of scutellarein under mild reaction conditions is still in demand. Results and discussion Our practical and economical five-step synthesis of scutellarein 1 is shown in Scheme 2. It was achieved in approximately 60% overall yield using the cheap 2,6-dimethoxy-1,4-benzoquinone as the starting material. WebFeb 1, 2024 · Scutellarin is the major active flavonoid extracted from the traditional Chinese herbal medicine Erigeron breviscapus (Vant.) Hand-Mazz., which is widely used in China. Recently, accumulating...
WebFeb 25, 2016 · Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This … WebSep 6, 2012 · In summary, an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin was reported. Essential to the synthesis was the use of H 2 SO 4 in 90% ethanol under a N 2 …
WebFeb 1, 2024 · Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells Scutellarin is the major active flavonoid extracted from the traditional Chinese herbal medicine Erigeron breviscapus (Vant.) Hand-Mazz., which is widely used in China.
WebIn summary, we have developed an efficient chemical synthesis of scutellarein (2) in high yield in only four steps. This strategy relies on acetylation, aldolization, cyclization and … preschool aquatics level 3WebTherefore, the present study focused on establishing an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin. The in vitro antioxidant activities of scutellarein were evaluated by measuring its scavenging capacities toward DPPH, ABTS + • , • OH free radicals and its protective effect on H2O2-induced cytotoxicity in ... scottish highland games gilbertWebThis kind of scutellarein derivative (3) could be an efficient agent for ischemic cerebrovascular disease treatment. Open in a separate window. Scheme 1. The route of the synthesis of scutellarein derivate (3). (a) H 2 SO 4, EtOH, 120 °C, 48 h, 17.3%; (b) H … preschool april newsletterWebJun 2, 2016 · Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant. For research use only. We do not sell to patients. Scutellarein Chemical Structure CAS No. : 529-53-3 Get it February 27 … preschool aqiWebOct 19, 2011 · Europe PMC is an archive of life sciences journal literature. preschool apronWebMay 1, 2024 · In this study, we designed, synthesized and evaluated a series of scutellarin and scutellarein-N,N-bis-substituted carbamate-l-amino acid derivatives as multifunctional therapeutic agents for the treatment of Alzheimer's disease (AD).Compounds containing scutellarein as the parent nucleus (6a–l) had good inhibitory activity against acetyl … scottish highland games itascaWebAbstract: In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at ... then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups. pre school apprenticeships